The 68th
Scientific Meeting
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| 19S-057 |
Analgesic Effect of Low Dose Nefopam Hydrochloride after Arthroscopic Rotator Cuff Repair
:A Randomized Controlled Trial
Department of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital,
College of Medicine, The Catholic University of Korea
BACKGROUND AND PURPOSE
Arthroscopic rotator cuff repair causes acute postoperative hyperalgesia. Multimodal analgesia is preferable to opioid-based intravenous patient-controlled analgesia (IV-PCA) due to postoperative nausea and vomiting (PONV). We evaluated the effect of nefopam as a postoperative non-opioid analgesic after shoulder surgeries.
MATERIALS AND METHODS
A total of 180 adult patients were enrolled for arthroscopic rotator cuff repair. They were randomly assigned to nefopam(N) or control(C) groups and each group was reclassified according to the interscalene block(B) into NB, CB and NX, CX. Nefopam was applied at a constant dose intravenously during recovery. Pain scores were measured with a Visual Analogue Scale (VAS) before (T0), immediately after (T1), 30min (T2) and 12h (T3), 24h (T4) and 48h (T5) after surgery.
RESULTS
There was no significant difference in demographic data. The overall VAS scores did not differ with regard to nefopam use, except for the NB group at T4 in intention to treat (ITT) analysis (p<0.05). PONV occurred more frequently in the N group than in the C group (p<0.05). Neither individual nor all risk factors were associated with PONV occurrence (p>0.10).
CONCLUSION
Nefopam alone did not show a definite decrease in postoperative pain. It instead increased PONV regardless of risk factors.
1. Uquillas,C.A.; Capogna,B.M.; Rossy,W.H.; Mahure,S.A.; Rokito,A.S. Postoperative pain control after arthroscopic rotator cuff repair. J.Shoulder Elbow Surg. 2016,25,1204
2. Yoo,Y.; Lee,C.; Cho,C.W.; Kim,W.J. Opioid sparing effect and safety of nefopam inpatient controlled analgesia after laparotomy: A randomized, double blind study. J.Int.Med.Res. 2016,44,844
Arthroscopic rotator cuff repair causes acute postoperative hyperalgesia. Multimodal analgesia is preferable to opioid-based intravenous patient-controlled analgesia (IV-PCA) due to postoperative nausea and vomiting (PONV). We evaluated the effect of nefopam as a postoperative non-opioid analgesic after shoulder surgeries.
MATERIALS AND METHODS
A total of 180 adult patients were enrolled for arthroscopic rotator cuff repair. They were randomly assigned to nefopam(N) or control(C) groups and each group was reclassified according to the interscalene block(B) into NB, CB and NX, CX. Nefopam was applied at a constant dose intravenously during recovery. Pain scores were measured with a Visual Analogue Scale (VAS) before (T0), immediately after (T1), 30min (T2) and 12h (T3), 24h (T4) and 48h (T5) after surgery.
RESULTS
There was no significant difference in demographic data. The overall VAS scores did not differ with regard to nefopam use, except for the NB group at T4 in intention to treat (ITT) analysis (p<0.05). PONV occurred more frequently in the N group than in the C group (p<0.05). Neither individual nor all risk factors were associated with PONV occurrence (p>0.10).
CONCLUSION
Nefopam alone did not show a definite decrease in postoperative pain. It instead increased PONV regardless of risk factors.
1. Uquillas,C.A.; Capogna,B.M.; Rossy,W.H.; Mahure,S.A.; Rokito,A.S. Postoperative pain control after arthroscopic rotator cuff repair. J.Shoulder Elbow Surg. 2016,25,1204
2. Yoo,Y.; Lee,C.; Cho,C.W.; Kim,W.J. Opioid sparing effect and safety of nefopam inpatient controlled analgesia after laparotomy: A randomized, double blind study. J.Int.Med.Res. 2016,44,844
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